Key result
Light transmission platelet aggregation and serotonin secretion assays were highly reproducible in patients with mucocutaneous bleeding, with normal and abnormal tests reproducible in 93.3% and 90.4%.
Why the study?
Do standardized light transmission platelet aggregation and serotonin secretion assays reliably diagnose mild platelet function disorders in patients with inherited mucocutaneous bleeding?
Population
213 patients with inherited mucocutaneous bleeding (MCB) and controls
Design
Cohort
Authors
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May support diagnostic use of these assays in mucocutaneous bleeding; leaves open prospective validation before changing practice.
Cross-Sectional (n=213)
Do standardized light transmission platelet aggregation and serotonin secretion assays reliably diagnose mild platelet function disorders in patients with inherited mucocutaneous bleeding?
p-value: p=<0.0001
Standardized platelet aggregation and serotonin secretion assays are highly reproducible and useful for diagnosing mild platelet function disorders, including isolated secretion defects.
Quiroga et al. (2009) conducted a cross-sectional in Inherited mucocutaneous bleeding (MCB) (n=213). Light transmission platelet aggregation and serotonin secretion assays vs. Controls was evaluated on Reproducibility of normal and abnormal PA tests (p=<0.0001). Light transmission platelet aggregation and serotonin secretion assays were highly reproducible in patients with mucocutaneous bleeding, with normal and abnormal tests reproducible in 93.3% and 90.4%.
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