Population
Mouse extensor digitorum longus and soleus muscles, n=59
Comparison
15 eccentric contractions in vitro; hindlimb… vs 15 isometric contractions in vitro; normal loading
Design
Preclinical
Follow-up
1 hour
Authors
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Should not inform clinical unloading protocols; leaves open fiber-type contributions to eccentric injury in human disuse models.
Eccentric contraction induces greater injury in normal EDL than soleus muscles, but unloading via hindlimb suspension increases susceptibility to injury in the soleus.
Warren et al. (1994) studied this question.
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