Key result
Eccentric contractions increase energetic cost ~53% vs isometric contractions in isolated mouse muscle.
Why the study?
It was unknown whether basal and/or active energy metabolism are altered in isolated mouse EDL muscle injured by eccentric contractions.
Does eccentric contraction injury alter basal and/or active energy metabolism in isolated mouse EDL muscle?
Population
Isolated mouse extensor digitorum longus muscle
Comparison
10 eccentric contractions vs 10 isometric contractions or no contractions
Design
Preclinical experimental study
Authors
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May reduce contraction economy after eccentric injury; hypothesis-generating for human muscle energetics.
Does eccentric contraction injury alter basal and/or active energy metabolism in isolated mouse EDL muscle?
Effect estimate: 53% higher
Absolute Event Rate: 2.35% vs 1.54%
Eccentric contraction injury in mouse EDL muscle decreases contraction economy due to uncoupling of ATP hydrolysis from force production and uncoupling of oxidative phosphorylation.
Warren et al. (1996) studied Eccentric contraction injury. Eccentric (Ecc) contractions vs. 10 isometric (Iso) or no contractions (No) was evaluated on Total energetic cost per force-time integral (53% higher). Eccentric contractions in isolated mouse EDL muscle increased the total energetic cost per force-time integral by 53% compared to isometric contractions (2.35 vs. 1.54 mumol O2/(N.m.s)).
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