Key result
Twenty eccentric contractions caused a 42.6% decrement in maximal isometric tetanic force compared to 3.9% for isometric contractions, indicating excitation failure prior to calcium release.
Population
Isolated mouse soleus muscles
Comparison
Eccentric contraction protocols vs Isometric contraction protocol
Design
Preclinical
Authors
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Suggests excitation failure may underlie eccentric injury force deficits in vitro; leaves open in vivo relevance and clinical implications.
Absolute Event Rate: 42.6% vs 3.9%
The force deficit in eccentric contraction-induced muscle injury results from a failure of the excitation process prior to calcium release by the sarcoplasmic reticulum, rather than structural damage to contractile elements.
Warren et al. (1993) studied Eccentric contraction-induced muscle injury (n=32). Eccentric contraction protocols vs. Twenty isometric contractions was evaluated on Decrements in maximal isometric tetanic force (P0). Twenty eccentric contractions caused a 42.6% decrement in maximal isometric tetanic force compared to 3.9% for isometric contractions, indicating excitation failure prior to calcium release.
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