What question did this study set out to answer?

This research aims to evaluate the effects of early versus late endurance training on left ventricular remodeling and survival following myocardial infarction in rats.

January 1, 1994CirculationOpen Access

Effect of endurance training early or late after coronary artery occlusion on left ventricular remodeling, hemodynamics, and survival in rats with chronic transmural myocardial infarction.

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Why the study?

Does endurance training initiated early or late after coronary artery occlusion improve LV remodeling, hemodynamics, and survival in rats with chronic transmural myocardial infarction?

Population

156 rats after coronary artery occlusion or sham operation

Comparison

Swim training started 4 days or 21 days after… vs Sedentary after coronary artery occlusion or…

Design

Preclinical, Randomized after coronary artery occlusion or sham operation

Follow-up

8 weeks

Authors

PGPeter GaudronKarolinska University Hospital KHKai HuSouth China Normal University RSR SchambergerRhön-Klinikum

Discussion

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Implication

Exercise post large MI raised mortality in rats (worse early); challenges exercise safety assumptions and leaves open human translation.

Key Points

This research aims to evaluate the effects of early versus late endurance training on left ventricular remodeling and survival following myocardial infarction in rats.
156 rats were randomized to sedentary or swim training starting 4 days or 21 days post-infarction for 8 weeks.
Hemodynamics and left ventricular (LV) dilation were assessed through passive pressure-volume curves at the end of the training period.
Morphological changes were measured through stained transverse LV sections for infarct size and remodeling.
Mortality was significantly higher in rats with large infarcts after endurance training (47.6% early, 26.7% late, P < .05).
LV volumes increased in sedentary rats with large infarcts compared to sham (0.48 +/- 0.04 mL) and both exercise groups (early: 0.56 +/- 0.04 mL, late: 0.65 +/- 0.04 mL, P < .05).
Nonsurvivors of early exercise showed severe LV dilation and shape distortion, with scar thinning and reduced septal thickness.

Structured PICO

Does endurance training initiated early or late after coronary artery occlusion improve LV remodeling, hemodynamics, and survival in rats with chronic transmural myocardial infarction?

Population

156 rats after coronary artery occlusion or sham operation

Intervention

Swim training started 4 days (early) or 21 days (late) after coronary occlusion, continued over 8 weeks (6 days per week, 90 minutes per day)

Comparator

Sedentary (no swim training) after coronary artery occlusion or sham operation

Outcome

Left ventricular remodeling, hemodynamics, and survival at 8 weekshard clinical

In a rat model of myocardial infarction, endurance training after a large infarction increased mortality and aggravated adverse left ventricular remodeling, particularly when initiated early.

Cite This Study

Gaudron et al. (1994) studied this question.

synapsesocial.com/papers/6a6f3b592163a0a01bc38f3f https://doi.org/10.1161/01.cir.89.1.402

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Effect of endurance training early or late after coronary artery occlusion on left ventricular remodeling, hemodynamics, and survival in rats with chronic transmural myocardial infarction.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of endurance training early or late after coronary artery occlusion on left ventricular remodeling, hemodynamics, and survival in rats with chronic transmural myocardial infarction.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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