Effect of exercise on acute myocardial infarction in rats
Key result
Early moderate exercise post-MI in rats does not worsen infarct size or LV topography.
- n=129
Why the study?
Does moderate exercise early after acute myocardial infarction affect infarct expansion or left ventricular topography in a rat model?
Population
129 rats with acute myocardial infarction induced by coronary artery ligation
Comparison
Treadmill exercise for 1.5 hours daily for 1… vs Remained in cages without exercise (n=39)
Design
Preclinical
Follow-up
1 week
Authors
Discussion
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Member takes
Implication
Hypothesis-generating in rat MI model; leaves open translation to human post-MI exercise timing.
Structured PICO
Does moderate exercise early after acute myocardial infarction affect infarct expansion or left ventricular topography in a rat model?
P
Population
129 rats with acute myocardial infarction induced by coronary artery ligation, followed for 1 week.
I
Intervention
Treadmill exercise for 1.5 hours daily for 1 week beginning on the day of coronary artery ligation (n=90)
C
Comparator
Remained in cages without exercise (n=39)
O
Outcome
Acute infarct expansion (prevalence and extent, including infarct wall thickness, left ventricular diameter, and expansion grade)surrogate
In a rat model of acute myocardial infarction, moderate early exercise did not significantly worsen infarct size or left ventricular remodeling, though a nonsignificant trend toward higher mortality was observed.
Cite This Study
Hochman et al. (1986) studied Acute myocardial infarction (n=129). Exercise on a treadmill vs. Remained in cages was evaluated on Infarct expansion (infarct wall thickness, left ventricular diameter and expansion grade). Moderate exercise early after myocardial infarction in rats produced no significant detrimental effect on infarct size or left ventricular topography.