Why the study?
Does strenuous exercise immediately after acute myocardial infarction cause adverse effects in an animal model?
Does strenuous exercise immediately after acute myocardial infarction cause adverse effects in an animal model?
In a preclinical dog model, strenuous exercise immediately following acute myocardial infarction did not worsen infarct size, cardiac rupture, or mortality.
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Supports early post-MI exercise safety in canine model; hypothesis-generating and leaves open human translation.
Animals exercised strenuously during two days after left anterior descending coronary artery occlusion, the first session being within one hour, showed no adverse effects compared with a control group. There was no increase in size of infarction, cardiac rupture, ventricular aneurysm, or mortality. Though peak heart rates exceeded 220/min, and in some animals rates as high as 300/min were reached, only two dogs showed major arrhythmias while exercising. This type of animal model may provide significant insights into the effects of exercise on the ischaemic myocardium.
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Thompson et al. (1973) studied this question.
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