Key result
Atorvastatin 40 mg/day for 6 months significantly increased the large artery elasticity index from 11.85 to 13.80 ml/mm Hg x 100 (P<0.001) in patients with coronary artery disease.
Why the study?
Does atorvastatin 40 mg/day improve arterial elasticity in dyslipidaemic patients with angiographically-proven CAD?
Cohort (n=33)
Does atorvastatin 40 mg/day improve arterial elasticity in dyslipidaemic patients with angiographically-proven CAD?
Intensive statin therapy with atorvastatin 40 mg/day for 6 months significantly improves large and small arterial elasticity in patients with CAD, independent of lipid changes.
May improve arterial elasticity in CAD; hypothesis-generating and requires RCT confirmation before practice change.
OBJECTIVE: Reduced arterial compliance is an independent predictor of cardiovascular mortality and is commonly encountered in patients with coronary artery disease. Statins may produce cholesterol-independent effects which can result at least in part from direct improvement of the arterial function. In this study, we sought to determine the effect of intensive statin therapy according to the Adult Treatment Panel III guidelines on arterial compliance in dyslipidaemic patients with angiographically-proven CAD selected for medical treatment. METHODS: Patients (n = 33) received atorvastatin 40 mg/day for 6 months. Large arterial compliance and small arterial compliance were measured at baseline and after 6 months of atorvastatin treatment. RESULTS: After treatment, the large artery elasticity index (LAEI) increased from 11.85 +/- 3.46 to 13.80 +/- 3.95 ml/mm Hg x 100 (P < 0.001) and the small artery elasticity index (SAEI) increased from 3.84 +/- 1.97 to 4.97 +/- 1.98 ml/mm Hg (P = 0.03). There was no correlation between the change in either LAEI or SAEI and other baseline variables or changes in lipid levels. CONCLUSION: Our findings suggest that intensive statin therapy according to the Adult Treatment Panel III guidelines improves arterial elasticity in CAD patients selected for medical treatment. The beneficial vascular effect of atorvastatin on arterial elasticity was independent of lipid parameters.
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Akgüllü et al. (2008) conducted a cohort in Coronary artery disease (n=33). Atorvastatin vs. Baseline was evaluated on Large artery elasticity index (LAEI) (p=<0.001). Atorvastatin 40 mg/day for 6 months significantly increased the large artery elasticity index from 11.85 to 13.80 ml/mm Hg x 100 (P<0.001) in patients with coronary artery disease.
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