Why the study?
Does the level of first-trimester hemoglobin A1 predict the risk of major malformations and spontaneous abortions in insulin-requiring diabetic gravidas?
Population
303 insulin-requiring diabetic gravidas who registered for prenatal care prior to 12 weeks' gestation and…
Comparison
First-trimester hemoglobin A1 (Hb A1) > 14.4% vs First-trimester hemoglobin A1 (Hb A1) ≤ 9.3%
Design
Cohort
Follow-up
Through pregnancy outcome
Authors
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Poor first-trimester control was associated with elevated malformation and abortion risks in diabetes; supports counseling but leaves optimal targets open for trials.
Does the level of first-trimester hemoglobin A1 predict the risk of major malformations and spontaneous abortions in insulin-requiring diabetic gravidas?
Very poor metabolic control in the first trimester markedly elevates the risk of major malformations and spontaneous abortions in diabetic pregnancies, though risks remain low across a broad range of acceptable control.
Greene et al. (1989) studied this question.
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