Why the study?
Does improved metabolic control reduce first trimester spontaneous abortions and major congenital malformations in pregnant women with insulin dependent diabetes mellitus?
Population
Pregnant women with insulin dependent diabetes mellitus
Comparison
Improved metabolic control of diabetes in the… vs Non-diabetic women
Design
Review
Authors
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Supports preconception optimization to normalize abortion risk; leaves open adjunctive strategies for persistent malformation risk.
Does improved metabolic control reduce first trimester spontaneous abortions and major congenital malformations in pregnant women with insulin dependent diabetes mellitus?
Women with insulin-dependent diabetes should aim for the best possible metabolic control prior to and throughout pregnancy to minimize risks of spontaneous abortions and major malformations.
Michael F. Greene (1999) studied this question.
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