January 1, 2020Pulmonary CirculationOpen Access

Role of natriuretic peptide receptor C signalling in obesity‐induced heart failure with preserved ejection fraction with pulmonary hypertension

Q: What is the clinical evidence from this study?

Study design: Letter. Population: Obesity-induced heart failure with preserved ejection fraction with pulmonary hypertension. Intervention: Natriuretic peptide receptor C (NPRC) signalling.

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Key result

Natriuretic peptide receptor C (NPRC) signaling is argued to be a critical protective pathway in the heart, potentially preventing right ventricular dysfunction in PH-HFpEF.

Design

Editorial

Authors

EEEmmanuel E. EgomHartford Hospital RKRené KamgangUniversité de Yaoundé I

Discussion

Member takes

Implication

This letter to the editor argues that NPRC signaling exerts protective effects in PH-HFpEF, challenging a recent study that proposed NPRC inhibition as a therapeutic target.

PICO

Population

Obesity-induced heart failure with preserved ejection fraction with pulmonary hypertension

Exposure / Comparator

Natriuretic peptide receptor C (NPRC) signalling

This letter to the editor argues that NPRC signaling exerts protective effects in PH-HFpEF, challenging a recent study that proposed NPRC inhibition as a therapeutic target.

Limitations

The critiqued study had a very small sample size (five mice per group for PH-HFpEF experiments).
The critiqued study may have been underpowered to detect smaller early differences in pulmonary vascular remodelling.
Original study discussed had a very small sample size (five mice per group for PH-HFpEF experiments; three mice per group for histologic analysis)

Cite This Study

Egom et al. (2020) conducted a letter in Obesity-induced heart failure with preserved ejection fraction with pulmonary hypertension. Natriuretic peptide receptor C (NPRC) signalling was evaluated. Natriuretic peptide receptor C (NPRC) signaling is argued to be a critical protective pathway in the heart, potentially preventing right ventricular dysfunction in PH-HFpEF.

synapsesocial.com/papers/6a6f3ec375498292b708a460 https://doi.org/10.1177/2045894020910975

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January 1, 2020Pulmonary CirculationOpen Access

Role of natriuretic peptide receptor C signalling in obesity‐induced heart failure with preserved ejection fraction with pulmonary hypertension

View Full Paper

Ask AI

Bookmark

Key result

Natriuretic peptide receptor C (NPRC) signaling is argued to be a critical protective pathway in the heart, potentially preventing right ventricular dysfunction in PH-HFpEF.

Design

Editorial

Authors

EEEmmanuel E. EgomHartford Hospital RKRené KamgangUniversité de Yaoundé I

Discussion

Member takes

Implication

This letter to the editor argues that NPRC signaling exerts protective effects in PH-HFpEF, challenging a recent study that proposed NPRC inhibition as a therapeutic target.

PICO

Population

Obesity-induced heart failure with preserved ejection fraction with pulmonary hypertension

Exposure / Comparator

Natriuretic peptide receptor C (NPRC) signalling

This letter to the editor argues that NPRC signaling exerts protective effects in PH-HFpEF, challenging a recent study that proposed NPRC inhibition as a therapeutic target.

Limitations

The critiqued study had a very small sample size (five mice per group for PH-HFpEF experiments).
The critiqued study may have been underpowered to detect smaller early differences in pulmonary vascular remodelling.
Original study discussed had a very small sample size (five mice per group for PH-HFpEF experiments; three mice per group for histologic analysis)

Cite This Study

synapsesocial.com/papers/6a6f3ec375498292b708a460 https://doi.org/10.1177/2045894020910975

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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