Key result
Mathematical modelling of cardiac ventricular myocytes demonstrated that acidosis-induced increases in intracellular sodium dominate changes in the intracellular calcium transient.
Population
Cardiac ventricular myocyte models
Comparison
Simulated acidosis vs Normal physiological pH conditions
Design
Preclinical
Authors
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Sodium-driven calcium shifts in myocyte models extend computational insights; leaves open validation and clinical relevance in acidosis.
Computational modeling demonstrates that increased sodium-calcium exchange driven by elevated intracellular sodium is the dominant mechanism altering the calcium transient during cardiac acidosis.
Crampin et al. (2006) studied Acidosis in cardiac ventricular myocytes. Simulated acidosis vs. Normal pH was evaluated on Intracellular Ca2+ transient and action potential. Mathematical modelling of cardiac ventricular myocytes demonstrated that acidosis-induced increases in intracellular sodium dominate changes in the intracellular calcium transient.
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