Key result
Exercise training may potentially ameliorate cardiovascular diseases by modulating RGS protein-mediated regulation of GPCR signaling, though specific cellular mechanisms remain to be explored.
This review outlines the cardioprotective role of RGS proteins in dampening exaggerated GPCR signaling and hypothesizes that the cardiovascular benefits of exercise may be mediated through RGS protein regulation.
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Does not yet alter exercise recommendations in CVD; leaves open RGS-GPCR mechanisms for targeted mechanistic studies.
The superfamily of G protein-coupled receptors (GPCR) are activated by biological molecules (e.g. neurotransmitters) and are involved in many physiological events. As exaggerated GPCR-mediated signaling may contribute to cardiovascular disorders, RGS proteins (regulators of G-protein signaling) are viewed as an important regulatory molecule for the negative modulation of this signaling pathway. To address the significance of RGS proteins and suggest potential effects of exercise training on this molecule, a literature review on RGS proteins was conducted.
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Hong et al. (2017) conducted a review in Cardiovascular Diseases. Exercise Training was evaluated. Exercise training may potentially ameliorate cardiovascular diseases by modulating RGS protein-mediated regulation of GPCR signaling, though specific cellular mechanisms remain to be explored.
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