Effects of tolazoline and prostacyclin on pulmonary hypertension in infants after cardiac surgery

14 infants (2 to 12 months old) with congenital heart disease and pulmonary hypertension requiring postoperative treatment for pulmonary vasospasm after corrective cardiac surgery, from a larger cohort of 42 monitored patients.

Tolazoline (0.5 mg/kg bolus, followed by 0.5 mg/kg/hr continuous IV infusion if effective) or prostacyclin (continuous IV infusion starting at 5 ng/kg/min, up to 15 ng/kg/min) for nonresponders to tolazoline.

Hemodynamic effects including mean pulmonary artery pressure and pulmonary vascular resistance.surrogate