Key result
The contraceptive patch was associated with an exaggerated decline in mean arterial pressure during orthostatic stress compared to controls and oral contraceptive users (P<0.05).
Why the study?
Does the transdermal contraceptive patch alter the renin-angiotensin-aldosterone system and hemodynamic response to orthostatic stress compared to oral contraceptive pills in healthy premenopausal women?
Population
35 nonsmoking, premenopausal women without evidence of cardiovascular disease, renal disease, or diabetes
Comparison
Transdermal contraceptive patch vs Oral contraceptive pill and no hormonal…
Design
Cross-sectional
Authors
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Should not yet change patch prescribing; leaves open RAAS-mediated orthostatic effects in premenopausal women.
Observational (n=35)
Does the transdermal contraceptive patch alter the renin-angiotensin-aldosterone system and hemodynamic response to orthostatic stress compared to oral contraceptive pills in healthy premenopausal women?
p-value: p=<0.05
The transdermal contraceptive patch is associated with an impaired ability to maintain blood pressure during orthostatic stress in healthy premenopausal women, possibly due to insensitivity of the endogenous RAAS.
Odutayo et al. (2015) conducted an observational in Healthy premenopausal women (n=35). Contraceptive patch (EVRA) vs. Oral contraceptive pill (OCP) and no hormonal contraception (controls) was evaluated on Baseline RAAS components and hormonal and hemodynamic responses to simulated orthostatic stress using incremental lower body negative pressure (p=<0.05). The contraceptive patch was associated with an exaggerated decline in mean arterial pressure during orthostatic stress compared to controls and oral contraceptive users (P<0.05).
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