Key result
Oral contraceptive agents elevated plasma renin activity and aldosterone excretion, with 51% of PRA and 23% of AER values >2 SD above the normal mean during the first week of use.
Why the study?
Do oral contraceptive agents increase plasma renin activity and aldosterone excretion rate in normal subjects?
Do oral contraceptive agents increase plasma renin activity and aldosterone excretion rate in normal subjects?
Oral contraceptive agents significantly increase plasma renin activity and aldosterone excretion rates in normal subjects, which may have implications for secondary hypertension.
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Oral contraceptive use was associated with elevated PRA and AER; hypothesis-generating for secondary hypertension and requires prospective validation.
Crane et al. (1969) studied Normal subjects (n=15). Oral contraceptive agents (Enovid-10, Orthonovum-10, Provest) vs. Normal mean was evaluated on Plasma renin activity (PRA) and aldosterone excretion rate (AER). Oral contraceptive agents elevated plasma renin activity and aldosterone excretion, with 51% of PRA and 23% of AER values >2 SD above the normal mean during the first week of use.
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