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September 10, 2025DiagnosticsOpen Access

Assessment of Preprocedural Factors Associated with 5-Year Complete Response After Transarterial Radioembolization in Patients with Hepatocellular Carcinoma

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Authors

JPJune ParkDKDong Kyu KimSLSeungsoo Lee

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Overview

Retrospective study reveals tumor diameter over seven centimeters predicts recurrence after radioembolization in hepatocellular carcinoma, suggesting tailored follow-up strategies.

Key Points

  • To identify preprocedural predictive factors associated with achieving a 5-year complete response following transarterial radioembolization (TARE) in patients with hepatocellular carcinoma.
  • Retrospective study evaluating 37 treatment-naïve patients with hepatocellular carcinoma (median age, 64 years) who underwent TARE between January 2016 and December 2019 with at least 5 years of follow-up.
  • Preprocedural liver dynamic MRI assessed tumor characteristics such as diameter, lesion count, satellite nodules, and portal vein thrombosis, with responses measured by modified Response Evaluation Criteria in Solid Tumors.
  • Multivariate logistic regression analysis was conducted to identify factors linked to 5-year tumor response.
  • Nine patients (24.3%) achieved a 5-year complete response without recurrence or additional therapy, whereas 28 patients (75.7%) had residual or recurrent tumors requiring further treatment.
  • Tumor diameters were significantly smaller in the complete response group compared to the non-complete response group (5.9 cm vs. 9.8 cm, p = 0.006).
  • A tumor diameter > 7 cm was the only independent factor significantly linked to recurrence (odds ratio = 21.277, p = 0.010), while portal vein thrombosis did not reach significance (odds ratio = 9.779, p = 0.063).

Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/6a6f41ba26a7f98052dbf941https://doi.org/10.3390/diagnostics15182297
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reevaluating complete response: Assessing whether imaging alone is sufficient to predict survival after transarterial radioembolization in hepatocellular carcinoma.2026
  2. 2Predictors of good outcomes in patients with hepatocellular carcinoma (HCC) treated with transarterial radioembolization (TARE).2024 · 1 citations
  3. 3Radiological Response and Characteristics of Patients Diagnosed With Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization: An Observational Study.2025
  4. 4Prognostic Value of Liver Biomarkers in Hepatocellular Carcinoma Patients Undergoing Yttrium 90 Transarterial Radioembolization (TARE): A Retrospective Pilot Study2024 · 3 citations
  5. 5Abstract No. 152 Tumor Size and Watershed Area Correlate with Incomplete Treatment and Tumor Progression After Segmental Radioembolization for Treatment-naïve and Solitary Hepatocellular Carcinoma.2024