Key result
Terlipressin (1 mg bolus) increased mean arterial pressure from 53.32 to 81.83 mmHg (P=0.002) in patients with refractory vasoplegic hypotension after cardiac surgery.
Why the study?
Does terlipressin bolus improve hemodynamics in patients with refractory vasoplegic hypotension after cardiac surgery?
Population
6 patients with norepinephrine-resistant postcardiotomy hypotension after cardiac surgery with…
Design
Case_series
Follow-up
3 hours
Authors
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May support terlipressin in refractory post-cardiac surgery vasoplegia; hypothesis-generating and requires RCTs before practice change.
Case Report (n=6)
Does terlipressin bolus improve hemodynamics in patients with refractory vasoplegic hypotension after cardiac surgery?
Absolute Event Rate: 81.83% vs 53.32%
p-value: p=0.002
Terlipressin bolus effectively increases systemic vascular resistance and mean arterial pressure in patients with refractory vasoplegic hypotension following cardiac surgery.
Noto et al. (2009) conducted a case report in Refractory vasoplegic hypotension after cardiac surgery (n=6). Terlipressin vs. Baseline (before terlipressin bolus) was evaluated on Mean arterial pressure (m-AP) (p=0.002). Terlipressin (1 mg bolus) increased mean arterial pressure from 53.32 to 81.83 mmHg (P=0.002) in patients with refractory vasoplegic hypotension after cardiac surgery.
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