Key result
In spontaneously breathing post-surgical patients, a perfusion index increase of ≥23% during a passive leg raising test predicted fluid responsiveness with 70% sensitivity and an AUC of 0.74.
Why the study?
Passive leg raising typically requires invasive stroke volume or cardiac output measurements, and the role of non-invasive perfusion index and pleth variability index for predicting fluid responsiveness in spontaneously breathing patients remains unclear.
Does the non-invasive perfusion index (PI) predict fluid responsiveness during a passive leg raising (PLR) test in spontaneously breathing post-surgical patients?
Population
47 spontaneously breathing post-major abdominal surgery patients in Italy
Comparison
Fluid responders vs non-responders during a passive leg raising test
Design
Prospective interventional study
Authors
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May support non-invasive PLR assessment via PI/PVI in circulatory failure; leaves open validation against invasive CO standards.
Observational (n=47)
No
Does the non-invasive perfusion index (PI) predict fluid responsiveness during a passive leg raising (PLR) test in spontaneously breathing post-surgical patients?
Absolute Event Rate: 41.2% vs 11.3%
p-value: p=0.010
The perfusion index (PI) provides a moderate, non-invasive method to predict fluid responsiveness during a passive leg raising test in spontaneously breathing post-surgical patients.
Rauch et al. (2025) conducted an observational in Post-surgical fluid responsiveness (n=47). Passive leg raising (PLR) test vs. Non-responders was evaluated on Percentage change in perfusion index (PI) from baseline to 60 s into the PLR test (p=0.010). In spontaneously breathing post-surgical patients, a perfusion index increase of ≥23% during a passive leg raising test predicted fluid responsiveness with 70% sensitivity and an AUC of 0.74.
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