Why the study?
Does subepicardial norepinephrine infusion induce ventricular arrhythmia and alter epicardial activation in anesthetized pigs?
Population
Anesthetized pigs and a computational model of a two-dimensional sheet of 256 x 256 resistively coupled…
Design
Preclinical
Authors
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Localized NE may slow conduction and trigger VT in pigs; leaves open relevance to human focal adrenergic arrhythmogenesis.
Does subepicardial norepinephrine infusion induce ventricular arrhythmia and alter epicardial activation in anesthetized pigs?
Adrenergic stimulation to a small region of the ventricle elicits triggered automaticity, implicating calcium overload as a mechanism for this type of arrhythmia.
Nash et al. (2001) studied this question.
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