Key result
Adult survivors of childhood lymphoma or acute lymphoblastic leukaemia had significantly lower right ventricular fractional area change compared to matched controls (44.5% vs. 48.6%, P<0.001).
Why the study?
Do adult survivors of childhood lymphoma or acute lymphoblastic leukaemia have impaired right ventricular function compared to matched controls?
Case-Control (n=457)
Do adult survivors of childhood lymphoma or acute lymphoblastic leukaemia have impaired right ventricular function compared to matched controls?
Absolute Event Rate: 44.5% vs 48.6%
p-value: p=<0.001
Adult survivors of childhood lymphoma and acute lymphoblastic leukaemia frequently exhibit impaired right ventricular systolic function, highlighting the need for long-term RV monitoring in this population.
RV surveillance may be considered in survivors; leaves open prognostic value and need for prospective trials.
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Christiansen et al. (2016) conducted a case-control in Childhood malignant lymphoma or acute lymphoblastic leukaemia (n=457). Survivorship of childhood lymphoma or acute lymphoblastic leukaemia vs. Matched controls was evaluated on Right ventricular fractional area change (p=<0.001). Adult survivors of childhood lymphoma or acute lymphoblastic leukaemia had significantly lower right ventricular fractional area change compared to matched controls (44.5% vs. 48.6%, P<0.001).
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