Population
Conscious normotensive and two-kidney, one clip Goldblatt hypertensive dogs
Comparison
Saralasin infused intravenously at 1… vs Normotensive dogs and untreated baseline state
Design
Preclinical
Follow-up
Acute (15 minutes to 2-3 hours)
Authors
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Saralasin effects limited to high-renin states in canine hypertension; leaves open translation to human renovascular disease.
In a canine model of renovascular hypertension, angiotensin II receptor blockade with saralasin reduces blood pressure and causes renal vasodilation primarily when the renin-angiotensin system is highly activated.
Zimmerman et al. (1980) studied this question.
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