Why the study?
Does saralasin infusion affect blood pressure and renal hemodynamics differently before and after sodium depletion in hypertensive patients?
Population
16 patients with hypertension (8 unilateral renovascular, 4 bilateral renovascular, and 4 essential)
Comparison
Intravenous administration of saralasin after… vs Intravenous administration of saralasin on…
Design
Other
Authors
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Sodium depletion may enhance saralasin response in hypertension; hypothesis-generating and should not yet change practice.
Does saralasin infusion affect blood pressure and renal hemodynamics differently before and after sodium depletion in hypertensive patients?
The hypotensive effect of angiotensin II blockade with saralasin is markedly enhanced by sodium depletion and correlates closely with baseline plasma renin activity, regardless of hypertension etiology.
Hoogdalem et al. (1978) studied this question.
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