Why the study?
Does saralasin infusion reduce mean arterial pressure in patients with hypertension under different sodium states?
Population
46 patients with hypertension of various aetiology
Comparison
Infusion of 1-sar-8-ala-angiotensin II before… vs Sodium replete state
Design
Cohort
Authors
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Limits saralasin's utility as a general diagnostic tool; leaves open targeted use with PRC assessment in hypertension.
Does saralasin infusion reduce mean arterial pressure in patients with hypertension under different sodium states?
The blood pressure response to the angiotensin II antagonist saralasin is highly dependent on sodium volume status and plasma renin concentration, limiting its clinical usefulness as a general diagnostic tool for hypertension.
Fagard et al. (1977) studied this question.
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