Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 1977Circulation Research

Pressor response to 1-sar-8-ala-angiotensin II (saralasin) in hypertensive subjects.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does saralasin infusion affect mean blood pressure in relation to plasma renin activity in untreated hypertensive subjects?

Population

418 untreated hypertensive subjects, along with a cohort of normal subjects for comparison.

Comparison

Saralasin intravenous infusion at 5 µg/kg per… vs Normal subjects and varying dietary sodium…

Design

Cross-sectional

Follow-up

1-day evaluation

Authors

GAGunnar H. AndersonJohn A. Hartford FoundationDSDavid H. P. StreetenCross-Cutting CardiologyTDTheodore G. DalakosSUNY Upstate Medical University

Discussion

Loading...

Member takes

Implication

Association supports renin profiling in select hypertensives; leaves open diagnostic or therapeutic utility.

Key Points

  • To examine the blood pressure response to saralasin infusion in untreated hypertensive subjects and evaluate its relationship with stimulated plasma renin activity and sodium balance.
  • Infused saralasin at 5 and 10 mcg/kg per min into 418 untreated hypertensive subjects and healthy control volunteers under unrestricted, low-sodium, and high-sodium diets.
  • Recorded blood pressure every 2 minutes using an Arteriosonde and determined plasma renin activity stimulated by intravenous furosemide and 2 hours of ambulation.
  • Saralasin produced a blood pressure increase of at least 7.0 mm Hg in 23% (97 of 418) of hypertensive subjects, showing an inverse correlation with stimulated plasma renin activity (r = -0.54, P < 0.001).
  • Pressor responders demonstrated lower stimulated plasma renin activity (1.3 ± 0.1 ng/ml per hour vs normal range 1.7–8.5) and significantly greater pressor sensitivity to angiotensin II than nonresponders (P < 0.01).
  • In normal subjects at 10 mcg/kg per min, saralasin produced no blood pressure change on an unrestricted diet, a significant fall on low sodium (P < 0.05), and a significant rise on high sodium (P < 0.005).

Structured PICO

Does saralasin infusion affect mean blood pressure in relation to plasma renin activity in untreated hypertensive subjects?

P
Population
418 untreated hypertensive subjects, along with a cohort of normal subjects for comparison.
I
Intervention
Saralasin (1-Sar-8-Ala-angiotensin II) intravenous infusion at 5 µg/kg per min and 10 µg/kg per min.
C
Comparator
Normal subjects and varying dietary sodium conditions (unrestricted, low sodium, and high sodium diets).
O
Outcome
Change in mean blood pressure and its correlation with stimulated plasma renin activity (PRA).surrogate

In untreated hypertensive subjects, a pressor response to saralasin occurs in about 23% of patients and is associated with salt loading, low stimulated plasma renin activity, and increased pressor sensitivity to angiotensin II.

Cite This Study

Anderson et al. (1977) studied this question.

synapsesocial.com/papers/6a8c06e37239707559bee0bdhttps://doi.org/10.1161/01.res.40.3.243

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Use of an Angiotensin II Antagonist (Saralasin) in the Recognition of “Angiotensinogenic” Hypertension1975 · 277 citations
  2. 2Identification of angiotensinogenic hypertension in man using 1-sar-8-ala-angiotensin II (Saralasin, P-113).1975 · 31 citations
  3. 3The Effect of Angiotensin II on the Blood Pressure in Humans with Hypertensive Disease*1964 · 258 citations
  4. 4Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin - angiotensin system.1975 · 116 citations
  5. 5Blockade and stimulation of renal, adrenal, and vascular angiotensin II receptors with 1-Sar, 8-Ala angiotensin II in normal man.1976 · 164 citations