Why the study?
Does saralasin administration after mild sodium depletion improve the detection of renin-mediated hypertension in patients with renovascular or essential hypertension?
Population
32 patients with renovascular (n=17) or essential hypertension (n=15)
Comparison
Saralasin administered before and after mild… vs Responses before sodium depletion compared to…
Design
Cohort
Follow-up
2 days
Authors
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May support saralasin testing after sodium depletion for renin-mediated hypertension detection; leaves open its added value versus renin assays in practice.
Does saralasin administration after mild sodium depletion improve the detection of renin-mediated hypertension in patients with renovascular or essential hypertension?
Saralasin testing during modest sodium depletion compares favorably with renin measurements for detecting renin-mediated hypertension.
Leonard S. Marks (1977) studied this question.
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