Why the study?
Does diuretic therapy alter the blood pressure response to saralasin infusion in patients with essential hypertension?
Population
41 subjects total: 34 patients (most with low-renin 'essential' hypertension) and 7 normal subjects.
Comparison
Diuretic therapy for 4 to 5 weeks, with infusion… vs Normal subjects and intra-patient baseline.
Design
Cohort
Follow-up
4 to 5 weeks
Authors
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Diuretic pretreatment may convert low-renin hypertension to angiotensin II dependence; hypothesis-generating and should not yet change practice.
Does diuretic therapy alter the blood pressure response to saralasin infusion in patients with essential hypertension?
Short-term diuretic therapy can convert some patients with low-renin essential hypertension into a state where their blood pressure is supported by angiotensin II.
Gunnar H. Anderson (1977) studied this question.
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