Key result
Saralasin infusion reduced blood pressure only in hypertensive patients with abnormally elevated basal plasma renin and angiotensin II levels, with a more marked reduction after sodium depletion.
Why the study?
Does saralasin infusion reduce blood pressure and alter the renin-angiotensin-aldosterone system in normal and hypertensive subjects?
Population
Normal subjects and hypertensive patients (evaluated in sodium replete and deplete states)
Design
Other
Authors
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Limits saralasin to high-renin cases; leaves open whether modern RAS inhibitors benefit similar patients.
Does saralasin infusion reduce blood pressure and alter the renin-angiotensin-aldosterone system in normal and hypertensive subjects?
Saralasin infusion demonstrates that renin and angiotensin II play a direct role in maintaining hypertension in patients with elevated basal plasma renin.
Brown et al. (1976) studied Hypertension. Saralasin infusion vs. Baseline / Normal subjects / Normal renin hypertensives was evaluated on Blood pressure and plasma aldosterone concentration. Saralasin infusion reduced blood pressure only in hypertensive patients with abnormally elevated basal plasma renin and angiotensin II levels, with a more marked reduction after sodium depletion.
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