What question did this study set out to answer?

To examine the initial blood pressure response to saralasin infusion and clarify its relationship with circulating catecholamines, renin-angiotensin markers, and fluid volume.

October 1, 1977Clinical Science

Plasma Catecholamines and the Pressor Response to Sar1-Ala8-Angiotensin II in Man

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Why the study?

Does saralasin infusion alter blood pressure and plasma catecholamines in normal subjects, hypertensive patients, and dialysis patients?

Key Points

To examine the initial blood pressure response to saralasin infusion and clarify its relationship with circulating catecholamines, renin-angiotensin markers, and fluid volume.
Infused saralasin (Sar1-Ala8-angiotensin II) into 15 healthy controls, 8 patients with untreated essential hypertension, and 65 patients on chronic hemodialysis (including 6 anephric patients).
Monitored arterial pressure and measured plasma renin activity, angiotensin II, adrenaline, noradrenaline, blood volume, and extracellular fluid volume.
A transient increase in arterial pressure peaked after 5–6 minutes in all healthy controls, hypertensive patients, anephric patients, and in 41 of 59 non-anephric hemodialysis patients.
Healthy controls experienced a 360% mean rise in plasma noradrenaline (P < 0.02) without adrenaline changes, which correlated directly with mean blood pressure elevation (P < 0.05).
Dialysis patients showed increased plasma noradrenaline (P < 0.005), but their blood pressure response correlated inversely with renin activity (P < 0.001) and angiotensin II (P < 0.001), positively with blood volume (P < 0.001), and not with noradrenaline.

Structured PICO

Does saralasin infusion alter blood pressure and plasma catecholamines in normal subjects, hypertensive patients, and dialysis patients?

Population

88 subjects including 15 normal subjects, 8 patients with untreated essential hypertension, and 65 patients established on chronic haemodialysis (including 6 anephric patients)

Intervention

Saralasin (Sar1-Ala8-angiotensin II) infusion

Outcome

Initial blood pressure response and its relation to plasma renin activity, angiotensin II, plasma catecholamines, blood volume, and extracellular fluid volumesurrogate

The pressor response to saralasin infusion is associated with increased plasma noradrenaline, suggesting mediation by the autonomic nervous system in addition to vascular receptors.

Discussion

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Implication

Requires caution during saralasin use; leaves open autonomic contributions to pressor responses in hypertension and dialysis.

Cite This Study

McGrath et al. (1977) studied this question.

synapsesocial.com/papers/6a90d48d647f40dea9c1a110 https://doi.org/10.1042/cs0530341

Topics

Hypertension management

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Plasma Catecholamines and the Pressor Response to Sar1-Ala8-Angiotensin II in Man

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Plasma Catecholamines and the Pressor Response to Sar1-Ala8-Angiotensin II in Man

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider