Why the study?
Does saralasin induce an immediate pressor response in hypertensive subjects, and how is it modulated by renin status and diuretic therapy?
Does saralasin induce an immediate pressor response in hypertensive subjects, and how is it modulated by renin status and diuretic therapy?
Saralasin induces an immediate pressor response mediated at the angiotensin II vascular receptor level, which is inversely correlated with baseline plasma renin activity and modulated by sodium/volume status.
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Saralasin-associated pressor responses vary by renin status and diuretics; hypothesis-generating for angiotensin receptor effects, prospective trials needed.
Carey et al. (1978) studied this question.
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