Why the study?
Does central (IVT) versus peripheral (IV) administration of the angiotensin II antagonist Saralasin differentially affect mean arterial pressure in various rat models of hypertension?
Population
Five different types of hypertensive unanesthetized rats and controls.
Comparison
Saralasin administered via intravenous infusions… vs Controls and comparison between IV and IVT…
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open a central angiotensin role in select hypertension models.
Does central (IVT) versus peripheral (IV) administration of the angiotensin II antagonist Saralasin differentially affect mean arterial pressure in various rat models of hypertension?
The dissociation of blood pressure responses to central versus peripheral angiotensin II blockade supports a role for locally formed brain angiotensin in blood pressure regulation in certain hypertensive rat models.
Mann et al. (1978) studied this question.
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