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November 1, 1983Journal of General Virology

Location of an Immunizing Determinant within Polypeptide VP1 of Type O Aphthovirus

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Population

Type O Aphthovirus and its structural polypeptide VP1

Design

Preclinical

Authors

JHJ. M. HaresnapeThe Open UniversityAKAndrew M. Q. KingThe Pirbright InstituteDMD. McCahonThe Pirbright Institute

Discussion

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Implication

Maps VP1 epitope in aphthovirus; leaves open relevance for vaccine antigen design.

Structured PICO

P
Population
Type O Aphthovirus and its structural polypeptide VP1
I
Intervention
Proteolytic cleavage using trypsin, chymotrypsin, and Staphylococcus aureus V8 protease
O
Outcome
Antigenic activity (ability to compete for virus-specific antibodies in serum raised against intact polypeptide)surrogate

The study identifies the location of a single immunizing determinant on the VP1 polypeptide of Type O Aphthovirus.

Cite This Study

Haresnape et al. (1983) studied this question.

synapsesocial.com/papers/6a6f5643ac440176ef280781https://doi.org/10.1099/0022-1317-64-11-2357
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Four Independent Antigenic Determinants on the Capsid Polypeptides of Aphthovirus1983 · 19 citations
  2. 2Immunogenic and Cell Attachment Sites of FMDV: Further Evidence for their Location in a Single Capsid Polypeptide1977 · 52 citations
  3. 3Location and Characterization of the Antigenic Portion of the FMDV Immunizing Protein1982 · 367 citations
  4. 4Identification of an exposed region of the immunogenic capsid polypeptide VP1 on foot-and-mouth disease virus1983 · 45 citations
  5. 5Relationship of the Antigenic Structure of Foot-and-Mouth Disease Virus to the Process of Infection1971 · 48 citations