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November 1, 1983Journal of General Virology

Four Independent Antigenic Determinants on the Capsid Polypeptides of Aphthovirus

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Population

Aphthovirus (foot-and-mouth disease virus) structural polypeptides VP1, VP2, and VP3

Design

Preclinical

Authors

JHJ. M. HaresnapeThe Open UniversityDMD. McCahonThe Pirbright Institute

Discussion

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Overview

Antigenic sites mapped in this model; leaves open their value for guiding vaccine strain selection in outbreaks.

Structured PICO

P
Population
Aphthovirus (foot-and-mouth disease virus) structural polypeptides VP1, VP2, and VP3
I
Intervention
Radioimmunoassay tests using antisera prepared against isolated structural polypeptides VP1, VP2, and VP3
O
Outcome
Identification and localization of antigenic determinants on the virus capsidsurrogate

The VP1-A determinant on the intact virion is likely of epidemiological importance as it induces neutralizing antibodies and shows variation among field strains.

Cite This Study

Haresnape et al. (1983) studied this question.

synapsesocial.com/papers/6a6f5643ac440176ef280780https://doi.org/10.1099/0022-1317-64-11-2345
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Location and Characterization of the Antigenic Portion of the FMDV Immunizing Protein1982 · 367 citations
  2. 2A Model for Foot-and-Mouth Disease Virus1972 · 42 citations
  3. 3Induction of Neutralizing Antibodies and Immunity in Vaccinated Guinea Pigs by Cyanogen Bromide-Peptides of VP3 of Foot-and-Mouth Disease Virus1977 · 57 citations
  4. 4Location of an Immunizing Determinant within Polypeptide VP1 of Type O Aphthovirus1983 · 7 citations
  5. 5Surface Structure of Foot-and-Mouth Disease Virus1969 · 117 citations