November 1, 1988Proceedings of the National Academy of SciencesOpen Access

Identification of an immunodominant antigenic site involving the capsid protein VP3 of hepatitis A virus.

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Population

Hepatitis A virus (neutralization-escape mutants)

Design

Preclinical

Authors

RJRobert W. JansenUniversity of North Carolina at Chapel Hill JSJack T. StapletonUniversity of Iowa JCJeffrey I. CohenNational Institutes of Health

Discussion

Member takes

Implication

Advances HAV antigenic mapping; leaves open translation to human vaccines or escape mutants.

Structured PICO

Population

Hepatitis A virus (neutralization-escape mutants)

Intervention

Sequencing of virion RNA and competitive binding studies with monoclonal antibodies

Outcome

Identification of immunodominant antigenic sitessurrogate

Residue 3070 of capsid protein VP3 contributes to an immunodominant antigenic site in the Hepatitis A virus, which is functionally related to residue 1102 of VP1.

Cite This Study

Jansen et al. (1988) studied this question.

synapsesocial.com/papers/6a85232fff13e6e4e743d2de https://doi.org/10.1073/pnas.85.21.8281

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Ask AI

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Identification of an immunodominant antigenic site involving the capsid protein VP3 of hepatitis A virus.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of an immunodominant antigenic site involving the capsid protein VP3 of hepatitis A virus.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider