January 10, 2017Proceedings of the National Academy of SciencesOpen Access

Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site

View Full Paper

Ask AI

Bookmark

Population

Hepatitis A virus (HAV) full and empty particles

Design

Preclinical

Authors

XWXiangxi WangHunan University LZLing ZhuUniversity of Electronic Science and Technology of China MDMinghao DangThe University of Texas MD Anderson Cancer Center

Discussion

Member takes

Implication

Does not support clinical translation; leaves open therapeutic development of capsid-destabilizing antibodies.

Structured PICO

Population

Hepatitis A virus (HAV) full and empty particles

Intervention

HAV-specific monoclonal antibody, R10

Outcome

Atomic details of antibody binding and receptor recognition sitesurrogate

The R10 monoclonal antibody neutralizes HAV by blocking host cell attachment and destabilizing the capsid, suggesting a receptor mimic mechanism that could inform therapeutic development.

Cite This Study

Wang et al. (2017) studied this question.

synapsesocial.com/papers/6a87ce78401d5d0676bb51c3 https://doi.org/10.1073/pnas.1616502114

View Full Paper

Ask AI

Bookmark

Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider