Population
Hepatitis A virus (HM-175 strain) and spontaneously arising mutants
Design
Preclinical
Authors
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Supports dominant HAV neutralization site for epitope vaccines; leaves open human translation of synthetic peptide candidates.
Hepatitis A virus possesses a single, dominant neutralization immunogenic site, suggesting it is a good candidate for synthetic peptide or antiidiotype vaccine development.
Stapleton et al. (1987) studied this question.
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