Population
Adenovirus virions, hexons, and antibodies
Design
Preclinical
Authors
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May guide adenovirus antigen selection for vaccines; leaves open in vivo neutralization mechanisms and human translation.
The study demonstrates that the mechanism of adenovirus neutralization by antibody is complex, with type-specific determinants exposed on the virion playing a crucial role despite impartial binding of both type-specific and cross-reactive antibodies.
Willcox et al. (1976) studied this question.
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