January 1, 1977Journal of General Virology

Biochemical Analysis of a Virulent and an Avirulent Strain of Foot-and-Mouth Disease Virus

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Population

Virulent (SAT1-7) and avirulent (SAT1-82) strains of foot-and-mouth disease virus, serotype SAT1

Design

Preclinical

Authors

THTimothy HarrisUniversity of California, Irvine FBF. BrownMaryland Institute College of Art

Discussion

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Implication

Shorter poly(C) tract may mark reduced SAT1 virulence; leaves open causal validation and relevance beyond this model.

Structured PICO

Population

Virulent (SAT1-7) and avirulent (SAT1-82) strains of foot-and-mouth disease virus, serotype SAT1

Intervention

Biochemical and serological analysis (cross-neutralization, immunodiffusion, polyacrylamide gel electrophoresis, hybridization, thermal denaturation, two-dimensional electrophoresis of oligonucleotides, sucrose gradient centrifugation)

Outcome

Differences in serological and physicochemical properties between the two strainssurrogate

The avirulent strain of foot-and-mouth disease virus SAT1 has a shorter poly(C) tract compared to the virulent strain, suggesting a potential molecular basis for virulence.

Cite This Study

Harris et al. (1977) studied this question.

synapsesocial.com/papers/6a6f56fcf44fa9f079dcc38d https://doi.org/10.1099/0022-1317-34-1-87

View Full Paper

Ask AI

Bookmark

Biochemical Analysis of a Virulent and an Avirulent Strain of Foot-and-Mouth Disease Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Biochemical Analysis of a Virulent and an Avirulent Strain of Foot-and-Mouth Disease Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider