Key result
Inoculation of pigs with live FMDV LL3BPVKV3DYR A24 virus resulted in 0% signs of disease or virus shedding across both administration routes, confirming the virus is highly attenuated.
Why the study?
Producing inactivated whole-virus vaccines requires growing large quantities of virulent FMD virus in biocontainment facilities, posing biosafety risks and high costs.
Absolute Event Rate: 0% vs 0%
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Highly attenuated FMDV LL3B3D A24 supports safer antigen production; leaves open efficacy and DIVA validation in field trials.
Eschbaumer et al. (2020) studied Foot-and-mouth disease (n=12). Live FMDV LL3BPVKV3DYR A24 virus (intradermal) vs. Live FMDV LL3BPVKV3DYR A24 virus (intra-oropharyngeal) was evaluated on Signs of disease or virus shedding. Inoculation of pigs with live FMDV LL3BPVKV3DYR A24 virus resulted in 0% signs of disease or virus shedding across both administration routes, confirming the virus is highly attenuated.
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