Key result
A peptide-based ELISA using 15-mer synthetic peptides from FMDV nonstructural proteins successfully discriminated between FMDV-infected and vaccinated cattle by detecting infection-specific antibodies.
A simple peptide-based assay using six identified linear B-cell epitopes can successfully discriminate between FMDV-infected and vaccinated cattle.
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May aid FMDV DIVA testing in cattle; leaves open validation for field deployment.
Höhlich et al. (2003) studied Foot-and-mouth disease (FMD). Peptide-based ELISA (15-mer synthetic peptides) vs. Sera from vaccinated cattle was evaluated on Detection of peptide-specific antibodies to differentiate infected from vaccinated cattle. A peptide-based ELISA using 15-mer synthetic peptides from FMDV nonstructural proteins successfully discriminated between FMDV-infected and vaccinated cattle by detecting infection-specific antibodies.
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