Key result
Vaccination of cattle with inactivated FMDV induces a cross-reactive CD8+ T cell response recognizing a highly conserved epitope within the structural protein P1D across all 7 FMDV serotypes.
p-value: p=<0.005
Identification of a highly conserved, cross-reactive CD8+ T cell epitope in FMDV could aid in the design of more effective, broadly protective vaccines for cattle.
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May guide conserved-epitope targeting for broad FMDV vaccines in cattle; leaves open field efficacy validation.
Guzman et al. (2010) studied Foot-and-Mouth Disease Virus (FMDV) immunity (n=10). Inactivated FMDV vaccine vs. Unvaccinated/uninfected controls or self-peptide was evaluated on Induction of IFN-gamma release and cytotoxicity by CD8+ T cells in response to FMDV peptides (p=<0.005). Vaccination of cattle with inactivated FMDV induces a cross-reactive CD8+ T cell response recognizing a highly conserved epitope within the structural protein P1D across all 7 FMDV serotypes.
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