Key result
Immunization with recombinant VP1 induced only low levels of neutralizing antibody and failed to elicit profound proliferative responses or protection in cattle.
Population
Bovine peripheral blood T lymphocytes from vaccinated and acutely infected cattle
Design
Preclinical
Authors
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Recombinant VP1 offers limited protection in cattle; leaves open whether other FMDV proteins drive cross-reactive T-cell responses.
T cell recognition of FMDV VP1 in cattle is serotype-specific, and recombinant VP1 immunization fails to elicit strong proliferative responses or protection, suggesting other viral proteins drive cross-reactive T cell responses.
Garcia-Valcarcel et al. (1996) studied Foot-and-mouth disease virus immunity. Vaccination with FMDV or recombinant VP1 vs. Acute infection was evaluated on Cellular recognition of FMDV and VP1 by peripheral blood T lymphocytes. Immunization with recombinant VP1 induced only low levels of neutralizing antibody and failed to elicit profound proliferative responses or protection in cattle.
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