Why the study?
Does exposure to FMD virus and its proteins induce specific lymphoproliferation in peripheral blood mononuclear cells from vaccinated cattle?
Population
Peripheral blood mononuclear cells from vaccinated cattle
Design
Preclinical
Authors
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May guide VP3-focused FMD vaccine design in cattle; leaves open confirmation of protective efficacy in field studies.
Does exposure to FMD virus and its proteins induce specific lymphoproliferation in peripheral blood mononuclear cells from vaccinated cattle?
FMD virus-induced lymphoproliferation in cattle is likely T cell-mediated, with VP3 containing dominant, cross-reactive sequences.
Collen et al. (1990) studied this question.
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