January 1, 1980Journal of VirologyOpen Access

Changes in three of the four coat proteins of oral polio vaccine strain derived from type 1 poliovirus

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Population

Sabin type 1 polio vaccine and parental Mahoney virus

Comparison

Tryptic comparison of coat proteins using… vs Parental Mahoney virus

Design

Preclinical

Authors

OKOlen M. KewCenters for Disease Control and Prevention MPMark A. PallanschNorthwestern University DODaniel R. OmilianowskiUniversity of Wisconsin–Madison

Discussion

Member takes

Implication

These substitutions benchmark Sabin 1 attenuation; leaves open their causal roles and generalizability to other enteroviruses.

Structured PICO

Population

Sabin type 1 polio vaccine and parental Mahoney virus

Intervention

Tryptic comparison of coat proteins using preparative gel electrophoresis with 3.5 M urea

Comparator

Parental Mahoney virus

Outcome

Amino acid replacements in coat proteinssurrogate

The Sabin type 1 polio vaccine strain coat proteins underwent approximately 10 to 13 amino acid replacements compared to the parental Mahoney virus during attenuation.

Cite This Study

Kew et al. (1980) studied this question.

synapsesocial.com/papers/6a6f5763a528af2d65c2f169 https://doi.org/10.1128/jvi.33.1.256-263.1980

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Changes in three of the four coat proteins of oral polio vaccine strain derived from type 1 poliovirus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Changes in three of the four coat proteins of oral polio vaccine strain derived from type 1 poliovirus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider