Population
Poliovirus type 1 (avirulent samples derived from neurovirulent Mahoney strain)
Design
Preclinical
Authors
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Suggests VP-1 alteration as attenuation marker in animal models; leaves open causal role and human relevance.
Avirulent strains of poliovirus type 1 exhibit an altered VP-1 capsid polypeptide compared to the neurovirulent Mahoney strain.
Milstien et al. (1977) studied this question.
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