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October 1, 1989PEDIATRICS

Kawasaki Disease in Families

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Population

1788 siblings of children with Kawasaki disease, based on questionnaires from the Japanese Association of…

Design

Cohort

Follow-up

1 year

Authors

YFYasuyuki FujitaAsahikawa Medical UniversityYNYosikazu NakamuraGeneral / Preventive / LipidsKSKiyomi SakataPreventive Cardiology

Discussion

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Implication

Supports close observation of young siblings after an index case; hypothesis-generating for familial risk factors in Kawasaki disease.

Structured PICO

P
Population
1788 siblings of children with Kawasaki disease, based on questionnaires from the Japanese Association of Parents of Children With Kawasaki Disease
C
Comparator
General population of children 0 to 4 years of age in Japan in the epidemic year 1982
O
Outcome
Rate of second-case Kawasaki disease occurring among siblings within 1 year after the onset of the first case in a familyhard clinical

Siblings of children with Kawasaki disease have a substantially higher risk of developing the disease than the general population, especially those under 2 years old and within 10 days of the index case.

Cite This Study

Fujita et al. (1989) studied this question.

synapsesocial.com/papers/6a6f57dd2163a0a01bc3a754https://doi.org/10.1542/peds.84.4.666
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nationwide Survey on Kawasaki Disease in Japan1987 · 88 citations
  2. 2Epidemiologic Pictures of Kawasaki Disease in Japan: From the Nationwide Incidence Survey in 1991 and 19921995 · 124 citations
  3. 3Incidence Survey of Kawasaki Disease in 1997 and 1998 in Japan2001 · 170 citations
  4. 4Increasing incidence of Kawasaki disease in Japan: Nationwide survey2008 · 100 citations
  5. 5Update of the Epidemiology of Kawasaki Disease in Japan1996 · 56 citations