December 1, 1997Journal of VirologyOpen Access

Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus

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Population

Empty capsids of foot-and-mouth disease virus (FMDV) type A22 Iraq 24/64

Comparison

X-ray crystallography structural analysis vs RNA-containing virus and poliovirus empty capsid

Design

Preclinical

Authors

Discussion

May guide antiviral design against picornaviruses; leaves open efficacy in human disease models.

Population

Empty capsids of foot-and-mouth disease virus (FMDV) type A22 Iraq 24/64

Intervention

X-ray crystallography structural analysis

Comparator

RNA-containing virus and poliovirus empty capsid

Outcome

Structural differences and capsid stabilization mechanismssurrogate

Structural analysis reveals that VP0 cleavage provides additional stability to the picornavirus capsid beyond RNA encapsidation.

Curry et al. (1997) studied this question.

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