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January 1, 1995Journal of VirologyOpen Access

Viral RNA modulates the acid sensitivity of foot-and-mouth disease virus capsids

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Population

Foot-and-mouth disease virus virions and natural empty capsids of three subtypes of serotype A (A22 Iraq…

Comparison

Low-pH-induced disassembly in vitro vs Virions vs natural empty capsids; comparison…

Design

Preclinical

Authors

SCStephen CurryUniversity of Nebraska–LincolnCACharles C. AbramsThe Pirbright InstituteEFElizabeth E. FryUniversity of Essex

Discussion

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Implication

May guide FMDV vaccine stability engineering; leaves open in vivo relevance and broader picornavirus applicability.

Structured PICO

P
Population
Foot-and-mouth disease virus (FMDV) virions and natural empty capsids of three subtypes of serotype A (A22 Iraq 24/64, A10(61), and A24 Cruzeiro)
I
Intervention
Low-pH-induced disassembly in vitro
C
Comparator
Virions vs natural empty capsids; comparison between subtypes
O
Outcome
Acid sensitivity / low-pH-induced disassemblysurrogate

Viral RNA modulates the acid lability of foot-and-mouth disease virus capsids, with empty capsids being more stable than virions.

Cite This Study

Curry et al. (1995) studied this question.

synapsesocial.com/papers/6a6f55f375498292b708bae0https://doi.org/10.1128/jvi.69.1.430-438.1995
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The pH Stability of Foot-and-Mouth Disease Virus Particles Is Modulated by Residues Located at the Pentameric Interface and in the N Terminus of VP12015 · 39 citations
  2. 2A Single Amino Acid Substitution in the Capsid of Foot-and-Mouth Disease Virus Can Increase Acid Resistance2010 · 43 citations
  3. 3A Single Amino Acid Substitution in the Capsid of Foot-and-Mouth Disease Virus Can Increase Acid Lability and Confer Resistance to Acid-Dependent Uncoating Inhibition2010 · 47 citations
  4. 4Negatively charged amino acids at the foot-and-mouth disease virus capsid reduce the virion-destabilizing effect of viral RNA at acidic pH2020 · 10 citations
  5. 5Characterization of synthetic foot-and-mouth disease virus provirions separates acid-mediated disassembly from infectivity1997 · 59 citations