Population
Human rhinoviruses (HRV 1A, HRV 2, HRV 14, HRV 1B) and poliovirus
Comparison
RNA-RNA hybridization and cross-neutralization… vs Poliovirus (negative control)
Design
Preclinical
Authors
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Genetic diversity among HRV serotypes cautions against assuming cross-immunity; leaves open homology-based vaccine targeting in humans.
The study demonstrates low genomic homology between different human rhinovirus serotypes (HRV 1A, 2, and 14), but high homology between antigenically related strains (HRV 1A and 1B).
Yin et al. (1973) studied this question.
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