Population
Poliovirus polymerase 3D(pol) mutants
Design
Preclinical
Authors
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Suggests potential for polymerase-mediated drug resistance; hypothesis-generating for escape mutant surveillance in vivo.
Strictly conserved residues in the nucleotide binding pocket of viral RNA-dependent RNA polymerases can be altered to support virus production, suggesting potential for drug-resistant escape mutants.
Crotty et al. (2003) studied this question.
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